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Feasibility of capillary velocity assessment by statistical means using dual‐beam spectral‐domain Optical Coherence Tomography: a preliminary study
Author(s) -
Daly Susan M.,
Silien Christophe,
Leahy Martin J.
Publication year - 2013
Publication title -
journal of biophotonics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.877
H-Index - 66
eISSN - 1864-0648
pISSN - 1864-063X
DOI - 10.1002/jbio.201200203
Subject(s) - optical coherence tomography , interferometry , optics , doppler effect , coherence (philosophical gambling strategy) , refractive index , representation (politics) , physics , computer science , tomography , frequency domain , biomedical engineering , biological system , computer vision , engineering , astronomy , politics , political science , law , biology , quantum mechanics
The assessment of vascular dynamics has been shown to yield both qualitative and quantitative metrics and thus play a pivotal role in the diagnosis and prognosis of various diseases, which may manifest as microcirculatory irregularities. Optical Coherence Tomography (OCT) is an established imaging modality which utilises the principle of optical interferometry to distinguish between spatial changes in refractive index and thus formulate a multi‐dimensional representation of a specimen in vivo . Nonetheless, difficulties remain in obtaining accurate data (morphological and/or transient) in an environment which is subject to such large biological variability. In an effort to address the issue of angular dependence as with Doppler based analysis, a dual‐beam Spectral‐domain OCT system for quasi‐simultaneous specimen scanning is described. A statistical based method of phase correlation is outlined which is capable of quantifying velocity values in addition to the ability to discern bidirectionality, without the necessity of angular computation. (© 2013 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)