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Imaging of e x vivo nonmelanoma skin cancers in the optical and terahertz spectral regions Optical and Terahertz skin cancers imaging
Author(s) -
Joseph Cecil S.,
Patel Rakesh,
Neel Victor A.,
Giles Robert H.,
Yaroslavsky An.
Publication year - 2014
Publication title -
journal of biophotonics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.877
H-Index - 66
eISSN - 1864-0648
pISSN - 1864-063X
DOI - 10.1002/jbio.201200111
Subject(s) - terahertz radiation , skin cancer , optics , terahertz spectroscopy and technology , materials science , optical imaging , optoelectronics , terahertz gap , medical imaging , medicine , terahertz metamaterials , cancer , far infrared laser , physics , laser , radiology
We tested the hypothesis that polarization sensitive optical and terahertz imaging may be combined for accurate nonmelanoma skin cancer (NMSC) delineation. Nine NMSC specimens were imaged. 513 μm and 440 nm wavelengths were used for terahertz and optical imaging, respectively. Histopathology was processed for evaluation. Terahertz reflectance of NMSC was quantified. Our results demonstrate that cross‐polarized terahertz images correctly identified location of the tumours, whereas cross‐polarized and polarization difference optical images accurately presented morphological features. Cross‐polarized terahertz images exhibited lower reflectivity values in cancer as compared to normal tissue. Combination of optical and terahertz imaging shows promise for intraoperative delineation of NMSC (© 2014 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)