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Lab‐on‐a‐chip biophotonics: its application to assisted reproductive technologies
Author(s) -
Lai David,
Smith Gary D.,
Takayama Shuichi
Publication year - 2012
Publication title -
journal of biophotonics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.877
H-Index - 66
eISSN - 1864-0648
pISSN - 1864-063X
DOI - 10.1002/jbio.201200041
Subject(s) - biophotonics , gamete , nanotechnology , microfluidics , automation , computer science , biology , materials science , engineering , photonics , optoelectronics , mechanical engineering , sperm , botany
With the benefits of automation, sensitivity and precision, microfluidics has enabled complex and otherwise tedious experiments. Lately, lab‐on‐a‐chip (LOC) has proven to be a useful tool for enhancing non‐invasive assisted reproductive technology (ART). Non‐invasive gamete and embryo assessment has largely been through periodic morpohological assessment using optical microscopy and early LOC ART was the same. As we realize that morphological assessment is a poor indication of gamete or embryo health, more advanced biophotonics has emerged in LOC ART to assay for metabolites or gamete separation via optoelectrical tweezers. Off‐chip, even more advanced biophotonics with broad spectrum analysis of metabolites and secretomes has been developed that show even higher accuracy to predicting reproductive potential. The integration of broad spectrum metabolite analysis into LOC ART is an exciting future that merges automation and sensitivity with the already highly accurate and strong predictive power of biophotonics. (© 2012 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)