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Detection of familial adenomatous polyposis with orthogonal polarized spectroscopy of the oral mucosa vasculature
Author(s) -
Basiri Ali,
Edelstein Daniel L.,
Graham Jenna,
Nabili Afshin,
Giardiello Francis M.,
RamellaRoman Jessica C.
Publication year - 2011
Publication title -
journal of biophotonics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.877
H-Index - 66
eISSN - 1864-0648
pISSN - 1864-063X
DOI - 10.1002/jbio.201100057
Subject(s) - familial adenomatous polyposis , colorectal cancer , medicine , gastroenterology , oral mucosa , pathology , cancer
Familial Adenomatous Polyposis (FAP) is an autosomal dominant disease characterized by the development of multiple colonic polyps at younger age with a near 100% lifetime risk of colorectal cancer. The determination of FAP is made after extensive clinical evaluation and genetic testing of at risk individuals. We investigated a novel spectro‐polarimetric imaging system capable of capturing high‐resolution images of the oral mucosa at different wavelengths in an attempt to distinguish patients with FAP from controls. Results of a clinical trial show that the system is capable of separating FAP positive individuals from controls by measuring the individuals' oral vascular density and complexity. (© 2011 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)