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Raman spectroscopy: a potential tool for early objective diagnosis of neoplasia in the oesophagus
Author(s) -
Almond L. Max,
Hutchings Joanne,
Shepherd Neil,
Barr Hugh,
Stone Nick,
Kendall Catherine
Publication year - 2011
Publication title -
journal of biophotonics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.877
H-Index - 66
eISSN - 1864-0648
pISSN - 1864-063X
DOI - 10.1002/jbio.201100041
Subject(s) - dysplasia , raman spectroscopy , medicine , pathology , radiology , optics , physics
There is a profound clinical need for a diagnostic tool that will enable clinicians to identify early neoplastic change in the oesophagus. Raman Spectroscopy (RS) has demonstrated the potential to provide non‐invasive, rapid, objective diagnosis of endoscopically invisible precancerous oesophageal dysplasia in vitro . RS analyses biological material to identify highly specific biochemical information that can be used to influence clinical care. Raman spectroscopic mapping could provide automated assessment of tissue biopsies to aid histopathological diagnosis in vitro . Furthermore, the recent development of fibre‐optic Raman probes has enabled endoscopic assessment of oesophageal mucosa in vivo . Accurate identification of dysplasia will enable targeted endoscopic resection of early lesions preventing the development of oesophageal cancer. This review summarises the development of Raman systems for use as laboratory based analytical adjuncts and endoscopic diagnostic tools in the distal oesophagus. (© 2011 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)