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Enhanced bioanalyte detection in waveguide confined Raman spectroscopy using wavelength modulation
Author(s) -
Ashok Praveen C.,
De Luca Anna Chiara,
Mazilu Michael,
Dholakia Kishan
Publication year - 2011
Publication title -
journal of biophotonics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.877
H-Index - 66
eISSN - 1864-0648
pISSN - 1864-063X
DOI - 10.1002/jbio.201000107
Subject(s) - analyte , raman spectroscopy , sensitivity (control systems) , modulation (music) , materials science , microfluidics , waveguide , wavelength , optoelectronics , surface enhanced raman spectroscopy , optics , nanotechnology , raman scattering , chemistry , chromatography , electronic engineering , acoustics , physics , engineering
Waveguide confined Raman spectroscopy (WCRS) incorporates a fibre based Raman detection system in a microfluidic platform enabling the spectroscopic detection of analyte. It offers the possibility to develop portable, alignment free devices for bio‐analyte sensing with minimal sample preparation. Ultimate sensitivity is limited by the fibre auto‐fluorescence background. Here we report enhanced bio‐analyte detection sensitivity by combining WCRS with continuous wavelength modulation technique. We used urea as a model analyte and the modulation parameters have been optimized to maximize the sensitivity of the device. (© 2011 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)