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Fiber‐optic probes for in vivo depth‐resolved neuron‐activity mapping
Author(s) -
DoroninaAmitonova Lyubov V.,
Fedotov Il'ya V.,
Ivashkina Olga I.,
Zots Marina A.,
Fedotov Andrei B.,
Anokhin Konstantin V.,
Zheltikov Aleksei M.
Publication year - 2010
Publication title -
journal of biophotonics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.877
H-Index - 66
eISSN - 1864-0648
pISSN - 1864-063X
DOI - 10.1002/jbio.201000041
Subject(s) - supercontinuum , in vivo , neuron , optical fiber , fluorescence , fiber , multiplex , materials science , nanotechnology , biophysics , optics , chemistry , photonic crystal fiber , neuroscience , biology , physics , bioinformatics , microbiology and biotechnology , composite material
Specialty fiber probes are used for in vivo depth‐resolved mapping of neuron activity through the optical detection of fluorescent‐protein reporters expressed inside the living brain of anesthetized transgenic mice. Supercontinuum radiation produced by highly nonlinear photonic‐crystal fibers is employed to demonstrate a simultaneous multicolor interrogation of several biomarkers in a model aqueous solution system, thus suggesting the way toward a multiplex mapping of various types of neuron dynamics inside the living brain. (© 2010 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)