Premium
Tissue viability (TiVi) imaging: temporal effects of local occlusion studies in the volar forearm
Author(s) -
McNamara Paul M.,
O'Doherty Jim,
O'Connell MarieLouise,
Fitzgerald Barry W.,
Anderson Chris D.,
Nilsson Gert E.,
Toll Rani,
Leahy Martin J.
Publication year - 2010
Publication title -
journal of biophotonics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.877
H-Index - 66
eISSN - 1864-0648
pISSN - 1864-063X
DOI - 10.1002/jbio.200910061
Subject(s) - microcirculation , forearm , provocation test , reactive hyperemia , medicine , occlusion , blood flow , human skin , biomedical engineering , dermis , pathology , surgery , radiology , biology , genetics , alternative medicine
Tissue Viability (TiVi) imaging is a promising new technology for the assessment of microcirculation in the upper human dermis. Although the technique is easily implemented and develops large amounts of observational data, its role in the clinical workplace awaits the development of standardised protocols required for routine clinical practice. The present study investigates the use of TiVi technology in a human, in vivo , localized, skin blood flow occlusion protocol. In this feasibility study, the response of the cutaneous microcirculation after provocation on the volar surface of the forearm was evaluated using a high temporal‐low spatial resolution TiVi camera. 19 healthy subjects – 10 female and 9 male – were studied after a localized pressure was applied for 5 different time periods ranging from 5 to 25 seconds. Areas corresponding to 100 × 100 pixels (2.89 cm 2 ) were monitored for 60 seconds prior to, during and after each occlusion period. Our results demonstrated the removal of blood from the local area and a hyperaemic response supporting the suitability of TiVi imaging for the generation of detailed provocation response data of relevance for the physiological function of the skin microcirculation in health and disease. (© 2010 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)