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Imaging of tumor vasculature using Twente photoacoustic systems
Author(s) -
Jose Jithin,
Manohar Srirang,
Kolkman Roy G. M.,
Steenbergen W.,
van Leeuwen Ton G.
Publication year - 2009
Publication title -
journal of biophotonics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.877
H-Index - 66
eISSN - 1864-0648
pISSN - 1864-063X
DOI - 10.1002/jbio.200910025
Subject(s) - photoacoustic imaging in biomedicine , biomedical engineering , radiology , medicine , computer science , medical physics , optics , physics
Abstract Photoacoustic imaging is a hybrid imaging modality based on the detection of acoustic waves generated by the absorption of short laser pulses in biological tissue. It combines the advantages of excellent contrast achieved in optical techniques with the high resolution of ultrasound imaging. In this article we present a review of the work done at the University of Twente to image tumor angiogenesis in vivo using this technique. We start with a description and the technical details of the different photoacoustic systems developed in our laboratory, with their validation on phantoms. We then discuss small‐animal studies with results of serial imaging of angiogenesis over a 10‐day period at the site of tumor induction in a rat. Further, we present clinical results using a photoacoustic mammoscope of breast cancer imaging based on angiogenesis‐driven optical absorption contrast. (© 2009 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)