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AM–FM techniques in the analysis of optical coherence tomography signals
Author(s) -
Pitris Costas,
Kartakoullis Andreas,
Bousi Evgenia
Publication year - 2009
Publication title -
journal of biophotonics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.877
H-Index - 66
eISSN - 1864-0648
pISSN - 1864-063X
DOI - 10.1002/jbio.200910023
Subject(s) - optical coherence tomography , modulation (music) , coherence (philosophical gambling strategy) , signal (programming language) , frequency modulation , optics , resolution (logic) , amplitude modulation , amplitude , contrast (vision) , computer science , physics , artificial intelligence , radio frequency , telecommunications , acoustics , quantum mechanics , programming language
The subtle tissue changes associated with the early stages of malignancies, such as cancer, are not clearly discernible even at the current, improved, resolution of optical coherence tomography (OCT) systems. However, these changes directly affect the spectral content of the OCT image that contains information regarding these unresolvable features. Spectral analysis of OCT signals has recently been shown to provide additional information, resulting in improved contrast, directly related to scatterer size changes. Amplitude modulation–frequency modulation (AM–FM) analysis, a fast and accurate technique for the estimation of the instantaneous frequency, phase, and amplitude of a signal, can also be applied to OCT images to extract scatterer‐size information. The proposed technique could make available an extremely valuable tool for the investigation of disease characteristics that now remain below the resolution of OCT and could significantly improve the technology's diagnostic capabilities. (© 2009 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)