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Plasmonic nanoprobes for SERS biosensing and bioimaging
Author(s) -
VoDinh Tuan,
Wang HsinNeng,
Scaffidi Jonathan
Publication year - 2010
Publication title -
journal of biophotonics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.877
H-Index - 66
eISSN - 1864-0648
pISSN - 1864-063X
DOI - 10.1002/jbio.200910015
Subject(s) - plasmon , biosensor , nanosensor , nanotechnology , raman scattering , materials science , molecular imaging , hyperspectral imaging , nanoparticle , raman spectroscopy , computer science , biology , optoelectronics , optics , physics , artificial intelligence , microbiology and biotechnology , in vivo
This article provides an overview of the development and application of plasmonic nanoprobes developed in our laboratory for biosensing and bioimaging. We describe the use of plasmonics surface‐enhanced Raman scattering (SERS) gene probes for the detection of diseases using DNA hybridization to target biospecies (HIV gene, breast cancer genes etc.). For molecular imaging, we describe a hyperspectral surface‐enhanced Raman imaging (HSERI) system that combines imaging capabilities with SERS detection to identify cellular components using Raman dye‐labeled silver nanoparticles in cellular systems The detection of specific target DNA sequences associated with breast cancer using “molecular sentinel” nanoprobes and the use of a plasmonic nanosensor to monitor pH in single cells are presented and discussed. (© 2010 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)