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Probing for local activity‐related modulation of the infrared backscattering of the brain cortex
Author(s) -
Biella Gabriele E. M.,
Trevisan Stefano,
Giardini Mario E.
Publication year - 2009
Publication title -
journal of biophotonics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.877
H-Index - 66
eISSN - 1864-0648
pISSN - 1864-063X
DOI - 10.1002/jbio.200810067
Subject(s) - signal (programming language) , brain cortex , neuroscience , computer science , brain activity and meditation , cortex (anatomy) , scalability , modulation (music) , biological system , physics , electroencephalography , biology , acoustics , database , programming language , endocrinology
The possibility to measure the metabolic activity of the brain cortex, with submillimeter spatial and subsecond temporal resolution, would open up enticing scenarios in addressing basic issues on the relation between different structural components of brain signal processing, and in providing an operational pathway to interaction with (dis)functional signal patterns. In the present article, we report the description of a simple system that allows the detection of the minute changes that occur in the optical backscattering of the cortex as a metabolic response to external stimuli. The simplicity of the system is compatible with scalability to an implantable probe. We validate the system on an animal model, and we propose an algorithm to extract meaningful data from the measured signal. We thus show the detection of individual haemodynamic cortical responses to individual stimulation events, and we provide operational considerations on the signal structure. (© 2009 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)