Premium
Optofluidic stretching of RBCs using single optical tweezers
Author(s) -
Mohanty S. K.,
Uppal A.,
Gupta P. K.
Publication year - 2008
Publication title -
journal of biophotonics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.877
H-Index - 66
eISSN - 1864-0648
pISSN - 1864-063X
DOI - 10.1002/jbio.200810001
Subject(s) - optical tweezers , viscoelasticity , adhesion , drag , tweezers , biophysics , materials science , chemistry , nanotechnology , optics , mechanics , composite material , biology , physics
Our previous studies demonstrated a huge difference in rotational speed of trapped red blood cells under diseased condition, which was presumably attributed to change in viscoelastic properties. Here, we report use of single optical tweezers combined with viscous drag for stretching of the trapped cell. Significant differences were observed in the measured viscoelastic parameters of fresh and aged/malaria‐infected RBCs under hypotonic condition. The technique was also found to provide information about adhesion properties of RBCs. (© 2008 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)