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Clinical multiphoton tomography
Author(s) -
König Karsten
Publication year - 2008
Publication title -
journal of biophotonics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.877
H-Index - 66
eISSN - 1864-0648
pISSN - 1864-063X
DOI - 10.1002/jbio.200710022
Subject(s) - autofluorescence , multiphoton fluorescence microscope , optical coherence tomography , preclinical imaging , fluorescence lifetime imaging microscopy , molecular imaging , two photon excitation microscopy , tomography , biomedical engineering , in vivo , medical physics , optics , medicine , fluorescence , materials science , radiology , fluorescence microscope , physics , microbiology and biotechnology , biology
Clinical multiphoton tomography and two‐photon microendoscopy provide clinicians and researchers with high‐resolution in vivo optical biopsies based on two‐photon autofluorescence, second harmonic generation, and fluorescence lifetime imaging. This review reflects state of the art technology and reports on applications in the fields of early stage melanoma detection, skin aging, nanoparticle imaging, tissue engineering, and in situ screening of pharmaceutical and cosmetical products. So far, more than 500 patients and volunteers in Europe, Asia, and Australia have been investigated with these novel molecular imaging tools. (© 2008 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)