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Protective effect of α ‐lipoic acid against chloroquine‐induced hepatotoxicity in rats
Author(s) -
Pari L.,
Murugavel P.
Publication year - 2004
Publication title -
journal of applied toxicology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.784
H-Index - 87
eISSN - 1099-1263
pISSN - 0260-437X
DOI - 10.1002/jat.940
Subject(s) - chloroquine , glutathione , tbars , chemistry , pharmacology , lipoic acid , aspartate transaminase , alpha lipoic acid , oral administration , toxicity , vitamin c , alkaline phosphatase , transaminase , vitamin , alanine transaminase , antioxidant , biochemistry , endocrinology , medicine , enzyme , immunology , organic chemistry , malaria
Abstract Oral administration of a‐lipoic acid, a metavitamin, was investigated for its possible hepatoprotective effect in Wistar rats against chloroquine‐induced toxicity. Rats were treated orally with α ‐lipoic acid (10, 30 and 100 mg kg −1 day −1 ) for 7 days before a single oral administration of chloroquine (970 mg kg −1 day −1 ) and α ‐lipoic acid treatment was continued for three more days. The increased level of serum enzymes (aspartate transaminase, alanine transaminase and alkaline phosphatase), bilirubin, lipids and plasma thiobarbituric acid‐reactive substances (TBARS) and hydroperoxides observed in rats treated with chloroquine were very much reduced in rats treated with α ‐lipoic acid plus chloroquine. A signicant decrease in plasma antioxidants such as reduced glutathione (GSH), vitamin C and vitamin E were observed in chloroquine‐treated rats when compared with control rats. Administration of α ‐lipoic acid signicantly improved the levels of plasma antioxidants GSH, vitamin C and vitamin E in chloroquine‐treated rats. In the case of 100 mg kg −1 day −1 the effect was highly signicant compared with the other doses (10 and 30 mg kg −1 day −1 ). The results of the study revealed that α ‐lipoic acid could offer protection against chloroquine‐induced hepatotoxicity. α ‐Lipoic acid had a better protective effect when compared with silymarin, a reference drug. Copyright © 2004 John Wiley & Sons, Ltd.