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Testicular and spermatotoxic effects of quinalphos in rats
Author(s) -
Pant N.,
Srivastava S. P.
Publication year - 2003
Publication title -
journal of applied toxicology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.784
H-Index - 87
eISSN - 1099-1263
pISSN - 0260-437X
DOI - 10.1002/jat.919
Subject(s) - quinalphos , sorbitol dehydrogenase , lactate dehydrogenase , sertoli cell , sperm , andrology , endocrinology , acid phosphatase , medicine , testicular atrophy , sperm motility , testicle , biology , alkaline phosphatase , enzyme , spermatogenesis , biochemistry , pesticide , agronomy
Testicular and spermatotoxic effects were investigated in rats exposed to technical‐grade quinalphos (70%) at dose levels of 0.52 mg kg −1 (1/50th ld 50 ) or 1.04 mg kg −1 body weight (1/25th ld 50 ) for 5 days a week for 60 days. The activities of marker testicular enzymes such as sorbitol dehydrogenase (SDH) and acid phosphatase were signicantly decreased but those of lactate dehydrogenase (LDH), γ ‐glutamyl transpeptidase ( γ ‐GT) and β ‐glucuronidase were signicantly increased in a dose‐dependent manner. This particular pattern in the activity of testicular‐cell‐specic enzymes, an decrease in sperm motility and total epididymal sperm count and an increase in abnormal sperm suggest damage to germ cells and Sertoli cells. The testicular and spermatotoxic effects observed in rats may be due to the pesticide quinalphos or its metabolites. Copyright © 2003 John Wiley & Sons, Ltd.