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Effect of zinc on hepatic lipid peroxidation and antioxidative enzymes in ethanol‐fed rats
Author(s) -
Pathak A.,
Mahmood A.,
Pathak R.,
Dhawan D.
Publication year - 2002
Publication title -
journal of applied toxicology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.784
H-Index - 87
eISSN - 1099-1263
pISSN - 0260-437X
DOI - 10.1002/jat.851
Subject(s) - lipid peroxidation , superoxide dismutase , catalase , glutathione peroxidase , chemistry , ethanol , zinc , medicine , endocrinology , antioxidant , enzyme , peroxidase , biochemistry , biology , organic chemistry
A 3‐ml aliquot of 30% ethanol was fed daily to normal as well as zinc‐treated (227 mg l −1 ) rats for periods of 2, 4 and 8 weeks. A highly significant increase in the levels of hepatic lipid peroxidation was observed in ethanol‐fed rats after 4 and 8 weeks of treatment. On the other hand, the levels of lipid peroxidation came down significantly following ethanol feeding to zinc‐treated rats. The activities of glutathione peroxidase (GPx), catalase and superoxide dismutase (SOD) in liver were elevated significantly after ethanol administration to rats for durations of 2, 4 and 8 weeks. Interestingly, zinc treatment to rats given ethanol was able to bring down the elevated levels of SOD, catalase and GPx to within normal limits, However, zinc administration alone did not cause any significant alteration in the activities of these antioxidative enzymes. Copyright © 2002 John Wiley & Sons, Ltd.