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Changes in concentrations of type IV collagen and tissue inhibitor of metalloproteinase‐1 in patients with paraquat poisoning
Author(s) -
Nakamura Tsukasa,
Ushiyama Chifuyu,
Shimada Noriaki,
Hayashi Kayo,
Ebihara Isao,
Suzaki Masataka,
Koide Hikaru
Publication year - 2001
Publication title -
journal of applied toxicology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.784
H-Index - 87
eISSN - 1099-1263
pISSN - 0260-437X
DOI - 10.1002/jat.779
Subject(s) - paraquat , medicine , tissue inhibitor of metalloproteinase , gastroenterology , ingestion , respiratory system , endocrinology , matrix metalloproteinase , chemistry , biochemistry
Respiratory failure is one of the major causes of death in patients with paraquat poisoning. In paraquat‐poisoned lungs, abnormal extracellular matrix regulation occurs. The aim of the present study is to determine whether serum concentrations of type IV collagen and tissue inhibitor of metalloproteinase‐1 (TIMP‐1) are altered during the course of paraquat poisoning and whether haemoperfusion therapy affects these concentrations. Twenty‐one patients were admitted within 3 h after ingestion of paraquat and all patients received direct haemoperfusion therapy. Five out of 21 patients survived and 16 patients died within 28 days. Plasma paraquat concentrations in non‐survivors (5740 ± 380 µg l −1 ) were not significantly different from those in survivors ( 5920 ± 280 µg l −1 ) before treatment. Haemoperfusion reduced these concentrations in both non‐survivors (120 ± 7 µg l −1 ) as well as survivors (136 ± 9 µg l −1 ) on day 5. Serum concentrations of type IV collagen and TIMP‐1 in survivors showed little change between day 1 (type IV collagen, 90.4 ± 3.6 ng ml −1 ; TIMP‐1, 172.2 ± 7.0 ng ml −1 ) and day 5 (type IV collagen, 92.6 ± 4.2 ng ml −1 ; TIMP‐1, 174.2 ± 7.2 ng ml −1 ). In contrast, these concentrations in non‐survivors on day 5 (type IV collagen, 143.6 ± 7.8 mg ml −1 ; TIMP‐1, 246.8 ± 13.6 ng ml −1 ) were significantly higher than those on day 1 (type IV collagen, 88.4 ± 4.2 ng ml −1 , P < 0.01; TIMP‐1, 170.6 ± 9.2 ng ml −1 , P < 0.05). These data suggest that serum concentrations of type IV collagen and TIMP‐1 may be useful indicators for the development of respiratory failure in patients with paraquat poisoning. Copyright © 2001 John Wiley & Sons, Ltd.