Premium
Detoxification of lantana hepatotoxin, lantadene A, using Alcaligenes faecalis
Author(s) -
Singh Anita,
Sharma Om P.,
Kurade Nitin P.,
Ojha Sudarshan
Publication year - 2001
Publication title -
journal of applied toxicology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.784
H-Index - 87
eISSN - 1099-1263
pISSN - 0260-437X
DOI - 10.1002/jat.746
Subject(s) - alcaligenes faecalis , hepatotoxin , lantana camara , microbiology and biotechnology , detoxification (alternative medicine) , lantana , enterococcus faecalis , incubation , chemistry , toxicity , biology , food science , bacteria , biochemistry , botany , medicine , pathology , escherichia coli , genetics , alternative medicine , organic chemistry , gene
Detoxification of lantadene A (LA), the hepatotoxin from Lantana camara var. aculeata , by the bacterial strain Alcaligenes faecalis has been investigated. Lantadene A induced hepatotoxicity concomitant with increases in plasma bilirubin, blood plasma enzymes and histopathological lesions that typify lantana toxicity. The extract of fermentation broth in which LA was incubated with A. faecalis did not elicit any alterations in blood enzyme prolife or liver histopathology, which were comparable with the control group. It is concluded that A. faecalis detoxified LA and no noxious product was formed on incubation of LA with A. faecalis . Copyright © 2001 John Wiley & Sons, Ltd.