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Radioprotective and locomotor responses of mice treated with nimodipine alone and in combination with WR‐151327
Author(s) -
Landauer M. R.,
Castro C. A.,
Benson K. A.,
Hogan J. B.,
Weiss J. F.
Publication year - 2001
Publication title -
journal of applied toxicology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.784
H-Index - 87
eISSN - 1099-1263
pISSN - 0260-437X
DOI - 10.1002/jat.728
Subject(s) - nimodipine , pharmacology , locomotor activity , neuroscience , medicine , psychology , calcium
The effect of combining a radiation‐protective phosphorothioate with another agent was investigated in an attempt to increase radioprotection and reduce toxicity. The calcium channel blocker nimodipine (NIMO) was administered alone (1 or 10 mg kg −1 ) or in combination with 200 mg kg −1 of the phosphorothioate radioprotector WR‐151327 (WR) (S‐3‐(3‐methylaminopropylamino)propylphosphorothioic acid). Radioprotection as measured (30‐day survival) of mice treated i.p. 30 min before 60 Co irradiation at a dose rate of 1 Gy min −1 ) was evaluated in CD2F1 male mice. The effects of nimodipine and WR‐151327 on locomotor activity were investigated also in a separate group of non‐irradiated mice. The LD 50/30 for the Emulphor vehicle control group was 8.56. For nimodipine alone (1 or 10 mg kg −1 ) the LD 50/30 was 8.39 and 10.21 Gy, respectively, yielding dose modification factors (DMFs) of 0.98 and 1.19, respectively. When WR‐151327 was given alone, the