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One‐year dog toxicity study of D‐002, a mixture of aliphatic alcohols
Author(s) -
Alemán Celia,
Rodeiro Idania,
Noa Miriam,
Menéndez Roberto,
Gaméz Rafael,
Hernandez Caridad,
Más Rosa
Publication year - 2001
Publication title -
journal of applied toxicology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.784
H-Index - 87
eISSN - 1099-1263
pISSN - 0260-437X
DOI - 10.1002/jat.705
Subject(s) - beagle , toxicity , medicine , food consumption , oral administration , body weight , physiology , drug , acute toxicity , pharmacology , agricultural economics , economics
Abstract D‐002 is a mixture of high‐molecular‐weight aliphatic alcohols, obtained from bees wax ( Apis mellifera ), with mild anti‐inflammatory properties and effective anti‐ulcer activities demonstrated in experimental models. This study investigated the oral toxicity of D‐002 administered for 1 year to beagle dogs. Twenty‐four beagle dogs (12 males and 12 females) were distributed randomly in three experimental groups (four animals per group): a control and two treated groups received D‐002 at 50 and 250 mg kg −1 (7 days/week) by gastric gavage. Overall, D‐002 was well tolerated throughout the study. No signs or symptoms of toxicity were observed, and no mortality occurred during the study. All groups showed similar weight gain and food consumption. No hematological, blood biochemical or histopathological disturbances attributable to treatment were observed. This study shows no drug‐related toxicity induced by long‐term administration of up to 250 mg kg −1 D‐002 to beagle dogs. Copyright © 2001 John Wiley & Sons, Ltd.