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Biomarkers of exposure, effect, and susceptibility in occupational exposure to traffic‐related air pollution: A review
Author(s) -
Brucker Natália,
Nascimento Sabriunes,
Bernardini Letícia,
Charão Mariele Feiffer,
Garcia Solange Cristina
Publication year - 2020
Publication title -
journal of applied toxicology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.784
H-Index - 87
eISSN - 1099-1263
pISSN - 0260-437X
DOI - 10.1002/jat.3940
Subject(s) - biomonitoring , exposure assessment , environmental health , occupational exposure , air pollution , xenobiotic , air pollutants , medicine , environmental science , toxicology , environmental chemistry , biology , ecology , chemistry , biochemistry , enzyme
There is a well‐recognized association between environmental air pollution exposure and several human diseases. However, the relationship between diseases related to occupational air pollution exposure on roads and high levels of traffic‐related air pollutants (TRAPs) is less substantiated. Biomarkers are essential tools in environmental and occupational toxicology, and studies on new biomarkers are increasingly relevant due to the need to determine early biomarkers to be assessed in exposure conditions. This review aimed to investigate the main advances in the biomonitoring of subjects occupationally exposed to air pollution, as well as to summarize the biomarkers of exposure, effect, and susceptibility. Furthermore, we discuss how biomarkers could be used to complement the current application of methods used to assess occupational exposures to xenobiotics present in air pollution. The databases used in the preparation of this review were PubMed, Scopus, and Science Direct. Considering the significant deleterious effects on health associated with chronic occupational exposure to xenobiotics, this topic deserves attention. As it is difficult to avoid occupational exposure to TRAPs, biomonitoring should be applied as a strategy to reduce the toxic effects of workplace exposure.