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In utero and lactational exposure to triclocarban: reproductive effects on female rat offspring
Author(s) -
Costa Nathália Orlandini,
Borges Lorena Ireno,
Cavalcanti Liara Freitas,
Montagnini Bruno Garcia,
Anselmo Franci Janete Aparecida,
Kiss Ana Carolina Inhasz,
Gerardin Daniela Cristina Ceccatto
Publication year - 2020
Publication title -
journal of applied toxicology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.784
H-Index - 87
eISSN - 1099-1263
pISSN - 0260-437X
DOI - 10.1002/jat.3922
Subject(s) - triclocarban , offspring , litter , lactation , gestation , physiology , medicine , in utero , reproductive toxicity , pregnancy , endocrinology , toxicity , biology , fetus , triclosan , pathology , genetics , agronomy
Triclocarban (TCC) is an antimicrobial compound widely used in personal care products such as soaps, toothpaste, and shampoo. This agent is incompletely removed by wastewater treatment and represents an environmental contaminant. Recent studies have shown that TCC is associated with some endocrine disruptions. The aim of the present study was to evaluate if TCC exposure during critical periods of development (gestation and lactation) could lead to adverse effects on reproductive and behavior parameters of female offspring. Pregnant female Wistar rats were divided into four groups ( n = 8–11/group): Control; TCC 0.3 mg/kg (TCC 0.3); TCC 1.5 mg/kg; TCC 3.0 mg/kg (TCC 3.0); and treated daily by oral gavage from gestational day 0 to lactational day 21. The female pups (F1 generation) were weaned on post‐natal day 21 and included in the study. No litter‐mates were used for the same group. There was a decrease in estradiol levels in the TCC 0.3 and TCC 3.0 groups. Moreover, there was a decrease in progesterone levels and an increase in pre‐implantation loss in the TCC 3.0 group in adulthood. It is suggested, in this study, that the decrease in progesterone biosynthesis could interfere with implantation process. The exposure window to TCC is an important factor, as we found alterations only in the offspring.