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Proflavine/acriflavine derivatives with versatile biological activities
Author(s) -
Sabolova Danica,
Kristian Pavol,
Kozurkova Mária
Publication year - 2020
Publication title -
journal of applied toxicology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.784
H-Index - 87
eISSN - 1099-1263
pISSN - 0260-437X
DOI - 10.1002/jat.3818
Subject(s) - proflavine , acriflavine , chemistry , cisplatin , cytotoxicity , antimicrobial , cytotoxic t cell , combinatorial chemistry , biochemistry , in vitro , biology , chemotherapy , organic chemistry , dna , genetics
Proflavine derivatives are extremely interesting chemotherapeutic agents, which have shown promising pharmaceutical potential due to their wide range of biological activities. This review summarizes the current state of research into the anticancer, antimicrobial, antimalarial and antileishmanial properties of these attractive compounds. Our attention has focused on new classes of proflavine conjugates, which display significant levels of anticancer activity. Highly promising cytotoxic properties have been identified in proflavine conjugates with imidazolidinones, ureas and thioureas. In particular, proflavine‐dialkyldithioureas displayed substantial cytotoxic effect against the human leukemia HL‐60 cells with IC 50 values from 7.2 to 34.0 μ m . As well, palladium complexes with proflavine ligand have important biologic activity. The LC 50 values of these complexes were significantly lower than that of cisplatin against the SK‐BR‐3 cell line.