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Combined effect of titanium dioxide nanoparticles and glucose on the cardiovascular system in young rats after oral administration
Author(s) -
Chen Zhangjian,
Zhou Di,
Wang Yun,
Zhao Lin,
Hu Guiping,
Liu Jiaxing,
Feng Huimin,
Long Changmao,
Yan Tenglong,
Zhou Shupei,
Jia Guang
Publication year - 2019
Publication title -
journal of applied toxicology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.784
H-Index - 87
eISSN - 1099-1263
pISSN - 0260-437X
DOI - 10.1002/jat.3750
Subject(s) - oral administration , histopathology , blood pressure , toxicity , pharmacology , body weight , medicine , blood sugar , physiology , chemistry , endocrinology , diabetes mellitus , pathology
Titanium dioxide nanoparticles (TiO 2 NPs) have already been used as food additive in various products and are usually consumed with a considerable amount of sugar. Oral consumption of TiO 2 NPs poses concerning health risks; however, research on the combined effect of ingested TiO 2 NPs and glucose is limited. We examined young Sprague‐Dawley rats administrated TiO 2 NPs orally at doses of 0, 2, 10 and 50 mg/kg body weight per day with and without 1.8 g/kg body weight glucose for 30 and 90 days. Heart rate, systolic and diastolic blood pressure, blood biochemical parameters and histopathology of cardiac tissues was assessed to quantify cardiovascular damage. The results showed that oral exposure to TiO 2 NPs and high doses of glucose both could induce cardiovascular injuries. The toxic effects were dose‐, time‐ and gender‐dependent. The interaction effects between oral‐exposed TiO 2 NPs and glucose existed and revealed to be antagonism in most of the biological parameters. However, toxic effects of the high‐dose glucose seemed to be more severe than TiO 2 NPs and the interaction of TiO 2 NPs with glucose. These results suggest that it may be more important to control the sugar intake than TiO 2 NPs for protecting the health of TiO 2 NP consumers.