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An updated weight of evidence approach for deriving a health‐based guidance value for 4‐nonylphenol
Author(s) -
Li Xiaomeng,
Huo Jiao,
Liu Zhaoping,
Yue Qianlan,
Zhang Lishi,
Gong Yunyun,
Chen Jinyao,
Bao Huihui
Publication year - 2019
Publication title -
journal of applied toxicology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.784
H-Index - 87
eISSN - 1099-1263
pISSN - 0260-437X
DOI - 10.1002/jat.3661
Subject(s) - adverse effect , reference dose , tolerable daily intake , nonylphenol , benchmark (surveying) , toxicology , european union , body weight , risk assessment , acceptable daily intake , medicine , no observed adverse effect level , food safety , environmental health , pharmacology , biology , computer science , chemistry , business , environmental chemistry , pesticide , computer security , geodesy , pathology , economic policy , geography , agronomy
4‐Nonylphenol (NP) is a persistent estrogen‐active compound. Human exposure to NP is primarily through water and food. Although risk assessments of NP have been conducted by the European Union and a few other countries, only the Danish Veterinary and Food Administration, in 2000, proposed a tolerable daily intake of 0.005 mg kg −1 body weight (bw) day −1 . New data have been accumulated since then, prompting an update on the risk assessment of NP. A weight of evidence approach is recommended for use in scientific assessments by several agencies, e.g., European Food Safety Authority, etc. Based on the results of a weight of evidence approach, two methods were used to derive the health‐based guidance value (HBGV) for NP in this study, namely a no observed adverse effects level/lowest observable adverse effect level method, and a benchmark dose method. Considering the considerable uncertainty of benchmark dose model fitting of the available data, a tolerable daily intake value of 0.025 mg kg −1 bw day −1 was derived as a provisional HBGV for NP based on the lowest observable adverse effect level value of 15 mg kg −1 bw day −1 of the renal toxicity in rats, together with the uncertainty factor of 600. However, the HBGV of NP still needs further investigation.