Premium
Multifunctional properties of novel tacrine congeners: cholinesterase inhibition and cytotoxic activity
Author(s) -
Sabolová Danica,
Kristian Pavol,
Kožurková Mária
Publication year - 2018
Publication title -
journal of applied toxicology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.784
H-Index - 87
eISSN - 1099-1263
pISSN - 0260-437X
DOI - 10.1002/jat.3622
Subject(s) - tacrine , cholinesterase , chemistry , pharmacology , combinatorial chemistry , acetylcholinesterase , biochemistry , biology , enzyme
This review describes the synthesis of a wide range of novel tetrahydroacridine derivatives (tiocyanates, selenocyanates, ureas, selenoureas, thioureas, isothioureas, disulfides, diselenides and several tacrine homo‐ and hetro‐hybrids). These tacrine congeners exhibit significant anticholinesterase and cytotoxic properties and may therefore be of considerable potential for the development of new drugs for the treatment of Alzheimer's disease.