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Early‐life exposure to Tris(1,3‐dichloroisopropyl) phosphate induces dose‐dependent suppression of sexual behavior in male rats
Author(s) -
Kamishima Manami,
Hattori Tatsuya,
Suzuki Go,
Matsukami Hidenori,
Komine Chiaki,
Horii Yasuyuki,
Watanabe Gen,
Oti Takumi,
Sakamoto Hirotaka,
Soga Tomoko,
Parhar Ishwar S.,
Kondo Yasuhiko,
Takigami Hidetaka,
Kawaguchi Maiko
Publication year - 2018
Publication title -
journal of applied toxicology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.784
H-Index - 87
eISSN - 1099-1263
pISSN - 0260-437X
DOI - 10.1002/jat.3569
Subject(s) - endocrine system , organophosphate , physiology , endocrinology , phosphate , medicine , androgen , sexual maturity , biology , chemistry , hormone , biochemistry , pesticide , agronomy
Exposure to endocrine‐disrupting chemicals may adversely affect animals, particularly during development. Tris(1,3‐dichloroisopropyl) phosphate (TDCIPP) is an organophosphate with anti‐androgen function in vitro that is present in indoor dust at relatively high concentrations. In male rats, androgens are necessary for the development of reproductive organs, as well as the endocrine and central nervous systems. However, we currently do not know the exact effects of TDCIPP exposure through suckling on subsequent reproductive behavior in males. Here, we show that TDCIPP exposure (25–250 mg kg –1 via oral administration over 28 consecutive days post‐birth) suppressed male sexual behavior and reduced testes size. These changes were dose‐dependent and appeared first in adults rather than in juveniles. These results demonstrate that TDCIPP exposure led to normal body growth and appearance in juveniles, but disrupted the endocrine system and physiology in adults. Therefore, assays should be performed using adult animals to ensure accuracy, and to confirm the influence of chemical substances given during early mammalian life.