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A review on acridinylthioureas and its derivatives: biological and cytotoxic activity
Author(s) -
Kožurková Mária,
Sabolová Danica,
Kristian Pavol
Publication year - 2017
Publication title -
journal of applied toxicology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.784
H-Index - 87
eISSN - 1099-1263
pISSN - 0260-437X
DOI - 10.1002/jat.3464
Subject(s) - acridine , chemistry , acridine derivatives , combinatorial chemistry , cytotoxic t cell , dna , intercalation (chemistry) , cancer cell lines , conjugate , cytotoxicity , stereochemistry , cancer cell , biochemistry , cancer , organic chemistry , biology , in vitro , genetics , mathematical analysis , mathematics
Acridines possess two characteristics that have led many researchers to consider the agents interesting targets for future development as potential farmacophores: the planar acridine skeleton, which is able to intercalate into DNA, and the intense fluorescence of the agents. This review offers a study of the multifunctional character of acridines and the synthesis of novel acridine derivatives, with particular focus being placed on isothiocyanates and their congeners, e.g. thioureas, isothioureas, quaternary ammonium salts and platinum/gold conjugates. The review provides an overview of the structure, spectral properties, DNA binding and biological activity of acridinylthiourea congeners. These acridinylthiourea derivatives display significant cytotoxic activities against different types of cancer cell lines at micromolar concentrations. Copyright © 2017 John Wiley & Sons, Ltd.