Premium
Biological factor related to Asian sand dust particles contributes to the exacerbation of asthma
Author(s) -
Honda Akiko,
Sawahara Takahiro,
Hayashi Tomohiro,
Tsuji Kenshi,
Fukushima Wataru,
Oishi Mizuki,
Kitamura Gaku,
Kudo Hitomi,
Ito Sho,
Yoshida Seiichi,
Ichinose Takamichi,
Ueda Kayo,
Takano Hirohisa
Publication year - 2017
Publication title -
journal of applied toxicology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.784
H-Index - 87
eISSN - 1099-1263
pISSN - 0260-437X
DOI - 10.1002/jat.3395
Subject(s) - immunology , exacerbation , immune system , proinflammatory cytokine , chemistry , medicine , biology , inflammation
Epidemiologic studies have revealed that Asian sand dust particles (ASDs) can affect respiratory and immune health represented by asthma. Factors responsible for the exacerbation of asthma remain unclear. The fungus Bjerkandera adusta ( B.ad ) and polycyclic aromatic hydrocarbons such as benzo[ a ]pyrene (BaP) have been identified in ASDs collected from the atmosphere when an ASD event occurred. We investigated the effects of B.ad and BaP related to ASDs on respiratory and immune systems. Bone marrow‐derived antigen‐presenting cells (APCs) and splenocytes from atopic prone NC/Nga mice and human airway epithelial cells were exposed to the B.ad or to BaP in the presence and absence of heated‐ASDs (H‐ASDs). B.ad and BaP in both the presence and absence of H‐ASDs increased the expression of cell surface molecules on APCs. H‐ASDs alone slightly activated APCs. The expressions induced by B.ad were higher than those induced by BaP in the presence and absence of H‐ASDs. There were no remarkable effects on the activation of splenocytes or the proinflammatory responses in airway epithelial cells. These results suggest that B.ad rather than BaP contributes to the exacerbation of asthma regardless of the presence or absence of sand particles, particularly by the activation of the immune system via APCs. Copyright © 2016 John Wiley & Sons, Ltd.