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Natural remedies for non‐steroidal anti‐inflammatory drug‐induced toxicity
Author(s) -
Simon Jerine Peter,
Evan Prince Sabina
Publication year - 2017
Publication title -
journal of applied toxicology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.784
H-Index - 87
eISSN - 1099-1263
pISSN - 0260-437X
DOI - 10.1002/jat.3391
Subject(s) - toxicity , diclofenac , drug , pharmacology , medicine , liver toxicity , adverse effect , drug toxicity
The liver is an important organ of the body, which has a vital role in metabolic functions. The non‐steroidal anti‐inflammatory drug (NSAID), diclofenac causes hepato‐renal toxicity and gastric ulcers. NSAIDs are noted to be an agent for the toxicity of body organs. This review has elaborated various scientific perspectives of the toxicity caused by diclofenac and its mechanistic action in affecting the vital organ. This review suggests natural products are better remedies than current clinical drugs against the toxicity caused by NSAIDs. Natural products are known for their minimal side effects, low cost and availability. On the other hand, synthetic drugs pose the danger of adverse effects if used frequently or over a long period. Copyright © 2016 John Wiley & Sons, Ltd.