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The toxic effects of indoor atmospheric fine particulate matter collected from allergic and non‐allergic families in Wuhan on mouse peritoneal macrophages
Author(s) -
Yan Biao,
Li Jinquan,
Guo Junhui,
Ma Ping,
Wu Zhuo,
Ling ZhenHao,
Guo Hai,
Hiroshi Yoshino,
Yanagi U.,
Yang Xu,
Zhu Shengwei,
Chen Mingqing
Publication year - 2016
Publication title -
journal of applied toxicology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.784
H-Index - 87
eISSN - 1099-1263
pISSN - 0260-437X
DOI - 10.1002/jat.3217
Subject(s) - oxidative stress , allergy , toxicity , immunology , allergic response , lipid peroxidation , medicine , particulates , biology , immunoglobulin e , antibody , ecology
Recent studies have shown that fine particulate matter (PM 2.5 ) is associated with multiple adverse health outcomes and PM 2.5 ‐induced oxidative stress is now commonly known as a proposed mechanism of PM 2.5 ‐mediated toxicity. However, the association between allergic symptoms in children and exposure to PM 2.5 has not been fully elucidated, particularly the role of PM 2.5 on the indoor environment involved in allergy or non‐allergy is unknown. The aim of the present study was to explore whether indoor PM 2.5 from the homes of children with allergic symptoms had more increased risks of allergy than that of healthy ones and then compare the toxicity and inflammatory response of them. In this study, indoor PM 2.5 was collected from the homes of schoolchildren with allergic symptoms and those of healthy ones respectively, and components of PM 2.5 were analyzed. PM 2.5 ‐mediated oxidative damage and inflammatory response were further evaluated in mouse peritoneal macrophages based on its effects on the levels of reactive oxygen species accumulation, lipid peroxidation, DNA damage or cytokine production. It seems that oxidative stress may contribute to PM 2.5 ‐induced toxicity, and PM 2.5 from the allergic indoor environment produced more serious toxic effects and an inflammatory response on mouse peritoneal macrophages than that from a non‐allergic indoor environment. Copyright © 2015 John Wiley & Sons, Ltd.