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Accumulation and toxicity of intravenously‐injected functionalized graphene oxide in mice
Author(s) -
Wen KaiPing,
Chen YingChieh,
Chuang ChiaHui,
Chang HwanYou,
Lee ChiYoung,
Tai NyanHwa
Publication year - 2015
Publication title -
journal of applied toxicology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.784
H-Index - 87
eISSN - 1099-1263
pISSN - 0260-437X
DOI - 10.1002/jat.3187
Subject(s) - spleen , biodistribution , toxicity , in vivo , lung , inflammation , nanomaterials , nanotoxicology , medicine , chemistry , pharmacology , acute toxicity , nanoparticle , nanotechnology , materials science , in vitro , biochemistry , biology , microbiology and biotechnology
Graphene and its functionalized derivatives have recently emerged as interesting nanomaterials with promising applications in biomedicine. In this study, the long‐term in vivo biodistribution of intravenously injected nanographene oxide (NGO) functionalized with poly sodium 4‐styrenesulfonate (PSS) was systematically examined and the potential toxicity over 6 months of NGO‐PSS nanoparticles was investigated. Our results showed that the nanoparticles mainly accumulate in the lung, liver and spleen, where they persist for at least 6 months. These nanoparticles result in acute liver injury and chronic inflammation of the lung, liver and spleen, as evidenced by blood biochemistry results and histological examinations. Copyright © 2015 John Wiley & Sons, Ltd.