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Hepatotoxicity mechanisms of isoniazid: A mini‐review
Author(s) -
Hassan Hozeifa M.,
Guo Hongli,
Yousef Bashir A.,
Luyong Zhang,
Zhenzhou Jiang
Publication year - 2015
Publication title -
journal of applied toxicology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.784
H-Index - 87
eISSN - 1099-1263
pISSN - 0260-437X
DOI - 10.1002/jat.3175
Subject(s) - isoniazid , metabolite , hydrazine (antidepressant) , liver injury , medicine , pharmacology , drug , tuberculosis , pathology
Isoniazid (INH) is an antituberculosis drug associated with idiosyncratic liver injury in susceptible patients. INH‐induced hepatotoxicity remains a significant clinical problem, but the underlying mechanisms are still unclear, despite the growing evidence that INH and/or its major metabolite, hydrazine, play an important role in hepatotoxicity. Copyright © 2015 John Wiley & Sons, Ltd.