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Organ‐specific distribution of gold nanoparticles by their surface functionalization
Author(s) -
Lee Jong Kwon,
Kim Tae Sung,
Bae Ji Young,
Jung A. Young,
Lee Sang Min,
Seok Ji Hyun,
Roh Hang Sik,
Song Chi Won,
Choi Mi Jin,
Jeong Jinyoung,
Chung Bong Hyun,
Lee YunGeon,
Jeong Jayoung,
Cho WanSeob
Publication year - 2015
Publication title -
journal of applied toxicology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.784
H-Index - 87
eISSN - 1099-1263
pISSN - 0260-437X
DOI - 10.1002/jat.3075
Subject(s) - surface modification , colloidal gold , nanoparticle , distribution (mathematics) , nanotechnology , materials science , chemistry , chemical engineering , mathematics , engineering , mathematical analysis
Abstract The behavior and fate of intravenously (i.v.) injected nanoparticles (NPs) can be controlled by several physicochemical factors including size, shape and surface charge. To evaluate the role of surface charge on distribution of NPs, we used neutral‐charged 15‐nm‐sized polyethylene glycol‐coated gold nanoparticles (AuNP PEG ) as a core NP and carboxyl or amine groups were conjugated to AuNP PEG to generate negative (AuNP COOH ) or positive AuNP (AuNP NH2 ), respectively. Each type of AuNP was i.v. injected into mice (1 mg kg –1 ) and the concentration of Au was measured in different organs at 30 min, 4, 24 h, 7, 14 days, 1, 3 and 6 months post‐injection. The organ distribution also showed the higher deposition rate depending on their functional groups: AuNP PEG for mesenteric lymph node, kidney, brain and testis; AuNP COOH for liver; AuNP NH2 for spleen, lung and heart. The blood circulation time and the major excretion route were different depending on their functional groups. In conclusion, functional groups conjugated on the surface of AuNPs produce differences in blood kinetics, organ distribution and elimination pattern which can be important information for directing NPs to specific organs or improving the kinetic properties. Copyright © 2014 John Wiley & Sons, Ltd.