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Prenatal exposure to bisphenol A at the reference dose impairs mitochondria in the heart of neonatal rats
Author(s) -
Jiang Ying,
Liu Juan,
Li Yuanyuan,
Chang Huailong,
Li Gengqi,
Xu Bing,
Chen Xi,
Li Weiyong,
Xia Wei,
Xu Shunqing
Publication year - 2014
Publication title -
journal of applied toxicology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.784
H-Index - 87
eISSN - 1099-1263
pISSN - 0260-437X
DOI - 10.1002/jat.2924
Subject(s) - mitochondrion , endocrinology , gestation , medicine , fetus , corn oil , heart disease , pregnancy , andrology , chemistry , biology , biochemistry , genetics
Bisphenol A (BPA) exposure has been reported to be epidemiologically associated with heart disease. As mitochondria play an important role in the early development of the heart and in the pathogenesis of heart disease, the current study investigated the possibility of cardiac mitochondrial injury in neonatal rat heart prenatally exposed to BPA. Pregnant Wistar rats were exposed to BPA 50 µg kg –1 day –1 or corn oil 1 ml kg –1 by oral gavage throughout gestation. Heart samples from pups on postnatal day 1 were isolated for analysis. Ultrastructure results showed mild swelling with dissociation of cristae in myocardial mitochondria of BPA‐treated rats. Additionally, mitochondrial membrane potential and the activity of respiratory chain complex II were significantly decreased. However, the activities of other three complexes (CI, CIII, CIV) and cardiac histology stayed normal. The expression levels of some key regulators involved in mitochondria energy metabolism and ATP‐generating pathways were downregulated. The study demonstrated for the first time that prenatal exposure to BPA at the reference dose could impair mitochondria in the hearts of neonatal rats. Copyright © 2013 John Wiley & Sons, Ltd.