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Induction and transfer of resistance to poisoning by Amorimia (Mascagnia) septentrionalis in goats
Author(s) -
Duarte Amélia L. L.,
Medeiros Rosane M. T.,
Carvalho Fabrício K. L.,
Lee Stephen T.,
Cook Daniel,
Pfister James A.,
Costa Valéria M. M.,
RietCorrea Franklin
Publication year - 2014
Publication title -
journal of applied toxicology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.784
H-Index - 87
eISSN - 1099-1263
pISSN - 0260-437X
DOI - 10.1002/jat.2860
Subject(s) - toxicity , acute toxicity , biology , resistance (ecology) , toxicology , pharmacology , medicine , agronomy
ABSTRACT Amorimia septentrionalis contains sodium monofluoroactetate (MFA) and can cause acute heart failure in ruminants when ingested in toxic doses. In this study, we demonstrate that resistance to poisoning by A. septentrionalis can be improved in goats by the repeated administration of non‐toxic doses of A. septentrionalis . We also show that increased resistance to poisoning by A. septentrionalis can also be achieved by the transfaunation of ruminal content from goats previously conditioned to be resistant to naïve goats. These methods of improving resistance require further study, but appear to provide potential management solutions to mitigate toxicity problems from A. septentrionalis , and perhaps other plant species containing MFA. Copyright © 2013 John Wiley & Sons, Ltd.