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Cytogenetic effects of rifampicin in somatic and germinal cells of the mouse
Author(s) -
AboulEla E. I.
Publication year - 1995
Publication title -
journal of applied toxicology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.784
H-Index - 87
eISSN - 1099-1263
pISSN - 0260-437X
DOI - 10.1002/jat.2550150415
Subject(s) - somatic cell , rifampicin , biology , genetics , immunology , antibiotics , gene
The genotoxicity of rifampicin was tested for sister chromatic exchange in bone marrow cells and for structural chromosomal aberrations in mouse germ cells. Sister chromatid exchange frequency increased after 160, 240 and 310 mg kg −1 body wt. doses but not after 80 mg kg −1 . In spermatocytes, 80 mg kg −1 rifampicin increased the frequency of chromosomal aberrations from the 3.5% control level to 14% after 1 day and 34.5% after 7 days.