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Evaluation of coal liquids derived from the eds process in carcinogenesis screening tests
Author(s) -
McKee R. H.,
Traul K. A.,
Przygoda R. T.
Publication year - 1995
Publication title -
journal of applied toxicology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.784
H-Index - 87
eISSN - 1099-1263
pISSN - 0260-437X
DOI - 10.1002/jat.2550150305
Subject(s) - salmonella , carcinogen , chemistry , coal , chromatography , liquefaction , hamster , coal liquefaction , environmental chemistry , toxicology , organic chemistry , bacteria , biology , microbiology and biotechnology , genetics
Four process streams derived from the EDS EDS is a designaiton for a direct coal liquefation process and was descriptive of an early stage in process development. direct coal liquefaction process were evaluated in two in vitro assays to screen for carcinogenic potential: the Salmonella /mammalian microsome mutagenicity assay and the Syrian hamster embryo morphologic transformation assay. Three high boiling liquids (two recycle solvents, nominal boiling range 200–425°C; and a fuel oil blend, nominal boiling range 200–538°C) were active in both assays. A hydrotreated naphtha sample (<200°C) was not active in either. The Salmonella data agreed qualitatively with results of dermal carcinogenesis studies; however, quantitative differences as measured by the estimation of mutagenic potency were apparent. The lack of quantitative agreement may have been related to the fact that the dermal carcinogenic activity of coal‐derived synthetic fuels is predominantly associated with neutral polycyclic aromatic hydrocarbons, whereas activity in the Salmonella assay is strongly influenced by the presence of aromatic amines and nitroaromatic compounds. Two modifications of the Salmonella assay—detergent disperson and hamster S9 activation—were examined. These techniques improved assay performance for some but not all of the coal liquids. The differences in response may have been related to compositional differences in the various liquids.