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Mechanism of citrinin‐induced dysfunction of mitochondria iii. Effects on renal cortical and liver mitochondrial swelling
Author(s) -
Chagas Generoso M.,
Oliveira Ma. Benigna M.,
Campello Annibal P.,
Klüppel Ma. Lúcia W.
Publication year - 1995
Publication title -
journal of applied toxicology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.784
H-Index - 87
eISSN - 1099-1263
pISSN - 0260-437X
DOI - 10.1002/jat.2550150206
Subject(s) - citrinin , mitochondrion , mechanism (biology) , kidney , chemistry , endocrinology , medicine , mycotoxin , biochemistry , food science , philosophy , epistemology
The effects of the mycotoxin citrinin on renal cortical and liver mitochondrial swelling were studied. Citrinin decreases the rate of swelling induced by the valinomycin–K + complex, suggesting that the mycotoxin interferes with the mitochondrial membrane fluidity. Citrinin promotes reduction of the amplitude of swelling in the presence of Na + ions. This alteration reflects interference with complex I of the respiratory chain and ATP synthase complex activity without disarranging the inner mitochondrial membrane, in view of the fact that the shrinkage was not affected. The effect increases with citrinin concentration. Renal tissue is more susceptible than hepatic tissue.