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Protective effect of colchicine on acute liver damage induced by CCL 4 . Role of cytochrome p‐450
Author(s) -
Martínez Martín,
Mourelle Marisabel,
Muriel Pablo
Publication year - 1995
Publication title -
journal of applied toxicology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.784
H-Index - 87
eISSN - 1099-1263
pISSN - 0260-437X
DOI - 10.1002/jat.2550150111
Subject(s) - colchicine , cytochrome , ccl4 , chemistry , pharmacology , lipid peroxidation , carbon tetrachloride , liver injury , biochemistry , medicine , antioxidant , biology , enzyme , organic chemistry
The aim of this work was to study if colchicine protects against CCl 4 ‐induced changes in hepatic biochemical parameters by reducing cytochrome P‐450, by comparing the effects of colchicine and SKF 525‐A, a well‐known inhibitor of cytochrome P‐450. Our results show that both drugs reduced the cytochrome P‐450 content and p ‐nitroanisole o ‐demethylase activity to the same extent. However, colchicine afforded a total protection from markers of liver injury, while SKF 525‐A protected only partially. The difference in the hepatoprotective activity of both drugs indicates that the beneficial effect of colchicine cannot be attributed solely to the inhibition of the activation of CCl 4 . Other actions, perhaps at the level of the propagation of lipid peroxidation or a ‘membrane‐stabilizing’ effect cannot be ruled out.