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Role of cellulose in wood dust‐induced fibrosing alveo‐bronchiolitis in rat
Author(s) -
Tátrai Frzsébet,
Adamis Zoltán,
Böhm Ute,
Merétey Katalin,
Ungváry György
Publication year - 1995
Publication title -
journal of applied toxicology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.784
H-Index - 87
eISSN - 1099-1263
pISSN - 0260-437X
DOI - 10.1002/jat.2550150110
Subject(s) - cellulose , fibrosis , superoxide , bronchiolitis , pathology , inflammation , pulmonary fibrosis , pathological , chemistry , medicine , immunology , biochemistry , virus , enzyme
Abstract Our experiments suggest that in the development of plant dust‐induced fibrosing alveobronchiolitis—Scadding's fibrosing alveolitis—the cellulose content of plant dusts has a decisive aetiological role. Namely, the wood dust (pine) and the cellulose induced morphologically identical granulomatous inflammation and fibrosis, whereas the fibre‐free extract of wood dust did not cause pathological changes in the lungs. The induction of H 2 O 2 and superoxide anion production, shown in vitro in leucocytes, probably has an important role in the development of fibrosis.