Premium
Liver lipid peroxidation and glutathione‐related defence enzyme systems in mice treated with paracetamol
Author(s) -
Özdemirler Gül,
Aykaç Gülçin,
Uysal Müjdat,
Öz Hikmet
Publication year - 1994
Publication title -
journal of applied toxicology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.784
H-Index - 87
eISSN - 1099-1263
pISSN - 0260-437X
DOI - 10.1002/jat.2550140410
Subject(s) - lipid peroxidation , glutathione , gpx4 , lipid peroxide , microsome , glutathione peroxidase , chemistry , biochemistry , enzyme , peroxidase , peroxide , microsoma , glutathione reductase , glutathione s transferase , endocrinology , medicine , biology , organic chemistry
Glutathione levels were found to be decreased while lipid peroxide levels were increased in total liver homogenates 6 h following paracetamol treatment (500 mg kg −1 i.p.). Furthermore, it has been determined that cytosolic glutathione S ‐transferase (GST) activity was decreased and glutathione peroxidase (GSH‐Px) activity remained unchanged. On the other hand, a decrease in liver microsomal lipid peroxide levels and an increase in GST and GSH‐Px activity has been observed. We concluded that decreased lipid peroxide levels in microsomes could be a consequence of increased GSH‐Px and GST enzyme activities. In this way, these glutathione‐related defence enzyme systems may play an important role in protecting microsomes from lipid peroxidation.