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The toxicity of seed extracts and their fractions from Lupinus angustifolius L. and Lupinus albus L.
Author(s) -
Stobiecki M.,
Blaszczyk B.,
KowalczykBronisz S. H.,
Gulewicz K.
Publication year - 1993
Publication title -
journal of applied toxicology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.784
H-Index - 87
eISSN - 1099-1263
pISSN - 0260-437X
DOI - 10.1002/jat.2550130509
Subject(s) - lupinus , lupinus angustifolius , biology , botany , toxicity , chemistry , organic chemistry
Seed extracts obtained from Lupinus albus and Lupinus angustifolius by treatment with 48% ethanol contained ca. 10% alkaloids (on a dry weight basis) and were non‐toxic. Their acute toxicity (LD 50 ) in the mouse is > 4000 mgkg −1 body wt. After fractionation, the extract from L. angustifolius seeds afforded several fractions with differing toxicities (LD 50 750–4000 mg kg −1 body wt.). None of the fractions tested in vitro were toxic. The results obtained showed that, in spite of the alkaloids, other low‐molecular‐weight constituents present significantly modified the toxicity of the lupin extracts.