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Mechanism of testicular atrophy induced by Di‐ n ‐butyl phthalate in rats. part 4. changes in the activity of succinate dehydrogenase and the levels of transferrin and ferritin in the sertoli and germ cells
Author(s) -
Fukuoka Masamichi,
Kobayashi Tetsu,
Zhou Yu,
Hayakawa Takao
Publication year - 1993
Publication title -
journal of applied toxicology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.784
H-Index - 87
eISSN - 1099-1263
pISSN - 0260-437X
DOI - 10.1002/jat.2550130406
Subject(s) - phthalate , transferrin , succinate dehydrogenase , ferritin , atrophy , testicular atrophy , succinic dehydrogenase , mechanism (biology) , endocrinology , chemistry , medicine , biochemistry , enzyme , philosophy , organic chemistry , epistemology
A single oral dose of di‐ n ‐butyl phthalate (DBP) to male rats caused a sloughing of the germ cells at 6 h both with a decrease in the activity of succinate dehydrogenase (SDH) in the Sertoli cells and in the Sertoli‐germ connection and with an increase in the activity of lactate dehydrogenase (LDH) in the germ cells. Increases in transferrin (Tf) concentrations were observed in the Sertoli cells, Sertoli‐germ connection, epididymis‐ductus deferens and liver of rats. Decreases in Tf and ferritin (Ft) levels were observed in the seminal vesicle and seminiferous lumen, respectively. An increase in favin adenine dinucleotide (FAD) level was found in the interstitial cells.