Premium
Mutagenic potential of nitroguanidine and nitrosoguanidine in the Drosophila melanogaster sex‐linked recessive lethal assay
Author(s) -
Gupta Raj K.,
Korte Don W.,
Reddy Gunda
Publication year - 1993
Publication title -
journal of applied toxicology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.784
H-Index - 87
eISSN - 1099-1263
pISSN - 0260-437X
DOI - 10.1002/jat.2550130404
Subject(s) - drosophila melanogaster , mutation , dominant lethal , microbiology and biotechnology , biology , genetics , chemistry , toxicology , gene
Abstract Nitroguanidine (NG) and its degradation product nitrosoguanidine (NSG) were evaluated for their mutagenic potential by using Drosophila melanogaster sex‐linked recessive lethal (SLRL) assay. Following 72 h of feeding exposure, NG and NSG at concentrations of 4–8 μg ml −1 and 15–20 mg ml −1 , respectively, were not mutagenic in the test system. The frequencies of mutations for NG and the negative control were 0.188% and 0.096%, respectively. The frequencies of mutations for NSG and the negative control experiments were 0.049% and 0.05%, respectively. The positive control mutation frequencies were 15% and 17.8% for the two assays. The differences between the mutation frequencies of NG and NSG and their negative controls were not significant.