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Delayed neurotoxic effect of sarin in mice after repeated inhalation exposure
Author(s) -
Husain K.,
Vijayaraghavan R.,
Pant S. C.,
Raza S. K.,
Pandey K. S.
Publication year - 1993
Publication title -
journal of applied toxicology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.784
H-Index - 87
eISSN - 1099-1263
pISSN - 0260-437X
DOI - 10.1002/jat.2550130212
Subject(s) - sarin , inhalation , inhalation exposure , toxicology , pharmacology , medicine , toxicity , neurotoxicity , nerve agent , anesthesia , chemistry , biology , acetylcholinesterase , biochemistry , enzyme
Delayed neurotoxicity of sarin in mice after repeated inhalation exposure has been studied. Female exposed to atmospheric sarin (5 mg m −3 for 20 min) daily for 10 days developed muscular weakness of the limbs and slight ataxia on the 14th day after the start of the exposure. These changes were accompanied by significant inhibition of neurotoxic esterase (NTE) activity in the brain, spinal cord and platelets. Histopathology of the spinal cord of exposed animals showed focal axonal degeneration. These changes were comparatively less than in animals treated with the neurotoxic organophosphate, mipafox. Results from this study indicate that sarin may induce delayed neurotoxic effects in mice following repeated inhalation exposure.