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Influence of methylamine and N,N '‐dimethylurea, the hydrolysis products of methyl isocyanate, on its systemic toxicity
Author(s) -
Jeevaratnam K.,
Sugendran K.,
Vaidyanathan C. S.
Publication year - 1993
Publication title -
journal of applied toxicology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.784
H-Index - 87
eISSN - 1099-1263
pISSN - 0260-437X
DOI - 10.1002/jat.2550130105
Subject(s) - chemistry , methylamine , isocyanate , hydrolysis , urea , toxicity , chromatography , albumin , organic chemistry , nuclear chemistry , biochemistry , polyurethane
Subcutaneous administration of the LD 50 dose of methyl isocyanate (MIC) to rats induced severe hyperglycaemia, lactic acidosis and uraemia in rats. Neither methylamine (MA) nor N,N′‐dimethylurea (DMU), the hydrolysis products of MIC, administered in equimolar doses had any influence on these parameters except for a marginal transient increase in plasma urea by DMU. Methyl isocyanate administration led to haemoconcentration, resulting in an increase in the plasma concentration of total proteins and a decrease in both the plasma concentration of albumin and the plasma cholinesterase activity. The hydrolysis products of MIC had no influence on any of these parameters. Thus, it seems reasonable to suggest that the systemic effects of MIC are caused by MIC per se , in spite of its high hydrolytic instability.