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Effects of 3‐methylcholanthrene or diethyl maleate on the hepatotoxicity of acetaminophen
Author(s) -
Szymańska J. A.,
Swietlicka E. A.,
Piotrowski J. K.,
SkrzypińskaGawrysiak M.,
Sporny S.
Publication year - 1992
Publication title -
journal of applied toxicology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.784
H-Index - 87
eISSN - 1099-1263
pISSN - 0260-437X
DOI - 10.1002/jat.2550120609
Subject(s) - methylcholanthrene , acetaminophen , toxicology , chemistry , pharmacology , medicine , carcinogen , organic chemistry , biology
This report presents a set of investigations on the hepatotoxic action of acetaminophen (AA). Male mice of Balb C strain were given [ 3 H]acetaminophen in doses of 100, 300 and 600 mg kg −1 with or without pretreatment with 3‐methylcholanthrene (3MCh) or diethyl maleate (DEM). The results of this study show that AA administered in moderate doses brings about necrotic changes due to adduct formation with macromolecules. Adduct formation was inversely correlated with the level of glutathione. Both modifiers enhanced hepatic necrosis and lethality. Diethyl maleate exerted these effects without enhancing covalent binding to macromolecules, while 3MCh increased both adduct formation and lipid peroxidation.