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Alteration of brainstem auditory evoked potentials in diethylbenzene and diacetylbenzene‐treated rats
Author(s) -
Gagnaire F.,
Becker M. N.,
de Ceaurriz J.
Publication year - 1992
Publication title -
journal of applied toxicology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.784
H-Index - 87
eISSN - 1099-1263
pISSN - 0260-437X
DOI - 10.1002/jat.2550120510
Subject(s) - brainstem , auditory brainstem response , medicine , audiology , neuroscience , chemistry , endocrinology , biology , hearing loss
Male Sprague‐Dawley rats were treated either with 1,2‐diethylbenzene (1,2‐DEB) or its putative active metabolite, 1,2‐diacetylbenzene (1,2‐DAB). Experimental rats and appropriate controls were examined electrophysiologically for brainstem auditory evoked potentials (BAEP). Oral administration of 1,2‐DEB (75 or 100 mg kg −1 once a day, 4 days a week, for 8 weeks) and intraperitoneal injection of 1,2‐DAB (10 or 15 mg kg −1 once a day, 4 days a week, for 8 weeks) produced time‐ and dose‐dependent increases in the peak latencies of all BAEP components as well as in interpeak (I–V) differences, and a decrease in the amplitudes of all the components. The absolute and interpeak latencies recovered partially during an 8‐week (1,2‐DEB) or a 10‐week (1,2‐DAB) recovery period, whereas there were long‐lasting decreases in peak amplitudes.